None of this combinatorial exploration was even thinkable before robotics and computers; now both of these technologies permit this brute force style of science.
The parameters of the emergent "library" of possibilities yielded by the sweep become the experiment.
I'm willing to bet the scientific method 400 years from now will differ from today's understanding of science more than today's science method differs from the proto-science used 400 years ago.
A sensible forecast of technological innovations in the next 400 years is beyond our imaginations (or at least mine), but we can fruitfully envision technological changes that might occur in the next 50 years.
(KEVIN KELLY:) Science will continue to surprise us with what it discovers and creates; then it will astound us by devising new methods to surprises us.
At the core of science's self-modification is technology.You can discover new algorithms by automatically generating all possible programs and then running them against the desired problem.Indeed all possible Xs of almost any sort can be summoned and examined as a way to study X.If new libraries of variations can be derived from the best of a previous generation of good results, it is possible to evolve solutions.The best results are mutated and bred toward better results.It removes one more variable (knowledge of experiment) and permits greater freedom in devising experiments from the indiscriminate data.Combinatorial Sweep Exploration – Much of the unknown can be explored by systematically creating random varieties of it at a large scale.The most powerful type of technology, sometimes called enabling technology, is a thought incarnate which enables new knowledge to find and develop news ways to know.This kind of recursive bootstrapping is how science evolves.Major journals have pledged not to publish the findings of phase 3 trials if their earlier phase 1 results had not been reported, whether negative or not.Triple Blind Experiments – In a double blind experiment neither researcher nor subject are aware of the controls, but both are aware of the experiment.